(06.03 MC)
Sickle cell anemia is known to run in a family. A pedigree chart for this family is shown below.
Parents
Offspring
What percentage of the offspring
are carriers of the disease but do not have it?
00%
O 25%
O 50%
© 100%

Based on the pedigree, the percentage of offspring who are carriers of sickle cell anemia is 50%.

Sickle cell anemia is a disease of the red blood cells in which mutations in the haemoglobin results in inability of the red blood cells to carry oxygen efficiently to the cells.

Based on the pedigree chart, the carriers of sickle cell are those that are half shaded black.

Two out of four of the offspring are shaded this way.

Percentage = 2/4 × 100% = 50%.

Therefore, the percentage of offspring who are carriers is 50%.

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