The basis for this immune response is the major histocompatibility complex (MHC) in the immune system.
What is the major histocompatibility complex?The major histocompatibility complex (MHC) is a gene complex that encodes cell surface molecules that are necessary for the acquired immune system to identify foreign antigens, usually proteins from invading microorganisms, and to distinguish them from self-antigens. This complex also plays a critical role in histocompatibility, or the compatibility of tissues and organs transplanted from one individual to another. Because MHC genes are highly polymorphic, meaning they vary greatly between individuals, they can be used to differentiate individuals and populations.
In humans, the major histocompatibility complex is also known as the human leukocyte antigen (HLA) system. There are three types of MHC genes, with classes I, II, and III. Classes I and II are critical for immune responses, while class III genes are involved in immune system regulation and other functions. MHC class I molecules are expressed on the surface of almost all nucleated cells and present peptides derived from intracellular proteins, while MHC class II molecules are found mainly on professional antigen-presenting cells such as dendritic cells, macrophages, and B cells, and present peptides derived from extracellular proteins.
Therefore, the immune system response against human tissues from different individuals is because of the major histocompatibility complex (MHC) in the immune system.
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why is it necessary for chromosomes to duplicate before mitosis
Chromosome duplication before mitosis ensures that each daughter cell receives a full complement of genetic material, which is essential for proper cell function and division.
Before mitosis, chromosomes must duplicate in order to make sure that each daughter cell has the entire complement of genetic material. The duplicated chromosomes of the cell are split into two identical sets during mitosis, and each set is subsequently packaged into a brand-new nucleus in one of the daughter cells. In the absence of chromosome duplication before mitosis, the daughter cells would only get half of the genetic material required for optimal function.
Prior to mitosis, in the S phase of the cell cycle, chromosome duplication takes place. The DNA double helix unwinds during this stage, and the complementary strands are then employed as templates to create new DNA strands. This produces sister chromatids, which are two identical copies of each chromosome joined together by a unique structure known as the centromere.
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Select the statement(s) that are true about science.
-Scientific laws are often revised to
include new evidence.
-Only scientific theories are able to be
changed with new evidence.
-Scientific
laws are not able to be modified.
-Scientific knowledge is able to exist, be
trusted as factual, and be changed with
new evidence.
-Scientific theories and ideas are not
able to be changed.
New evidence
means the original thought must be
discarded.
-A scientific theory is supported by
evidence and continues to be a theory,
even when it is changed due to new
evidence.
Scientific knowledge is able to exist, be trusted as factual, and be changed with new evidence is the correct statement .
What is science ?Science is the search and application of knowledge and understanding of the natural and social worlds through a methodical and evidence-based methodology.
The following are examples of scientific methodology:
Observation objective: Data collection and measurement (possibly although not necessarily using mathematics as a tool)
Evidence
Experimentation and/or observation serve as yardsticks for testing hypotheses.
Induction: reasoning to construct broad principles or conclusions based from facts or examples
Repetition
Critical thinking
Verification and testing: critical inspection, peer review, and evaluation
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the diagram shows a large food molecule changing into smaller molecules?
what's process X?
Answer: Process X is digestion.
Explanation: Digestion breaks down food into smaller pieces so that it can process through the body.
The process of large food changing into smaller molecules by the process X, that process is called Digestion. In depth if the process is known to be digestion, then the process X by which the food is broken down is called hydrolysis.
Hydrolysis is a chemical reaction that breaks down large molecules into smaller ones through the addition of water molecules.
In digestion, hydrolysis is used to break down complex macromolecules such as carbohydrates, proteins, and lipids into simpler molecules that can be absorbed and utilized by the body.
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apes which statement about emerging infectious diseases is not true? bird flu is a virus that jumps from birds to people. ebola hemorrhagic fever causes a high rate of death. mad cow disease is spread when cows are fed grain in large feedlots. hiv is a virus that most likely came from chimps.
All of the statements are true in the context of emerging infectious diseases
Bird flu (avian influenza) is a virus that is primarily found in birds, but it can occasionally infect humans who come into close contact with infected birds or their feces. This virus can cause serious illness or even death in humans, and there is concern that it could lead to a pandemic if it mutates to a form that can spread easily between people.
Ebola hemorrhagic fever is a highly infectious and often deadly disease caused by the Ebola virus. It is typically spread through contact with bodily fluids of infected animals or humans, and there have been several outbreaks in Africa that have caused significant illness and death.
Mad cow disease (bovine spongiform encephalopathy) is a prion disease that affects cows and is believed to be caused by feeding cows contaminated meat and bone meal. Humans can develop a similar disease called variant Creutzfeldt-Jakob disease (vCJD) by consuming infected beef products.
HIV (human immunodeficiency virus) is a virus that attacks the immune system and can lead to acquired immunodeficiency syndrome (AIDS). The virus is believed to have originated in chimpanzees in Africa and is thought to have spread to humans through the consumption of bushmeat (meat from wild animals).
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which other cellular components are likely to be located near the lacy6xbs transcript in the cell membrane?
The cellular components that are likely to be located near the lacy6xbs transcript in the cell membrane are lactose permease and beta-galactosidase.
The cell membrane is a thin, flexible, and selectively permeable membrane that surrounds the cell. The following are the components of the cell membrane:
PhospholipidsProteinsCholesterolCarbohydratesThe cell membrane's primary function is to protect the cell and regulate the flow of materials in and out of it. The cell membrane is also responsible for the cell's communication with the extracellular environment. Lactose permease is a protein found in the cell membrane that helps transport lactose into the cell.
Lactose permease is the first step in lactose metabolism. Beta-galactosidase, on the other hand, is an enzyme that aids in the breakdown of lactose into glucose and galactose. Beta-galactosidase also has a regulatory role in gene expression.
Both lactose permease and beta-galactosidase are proteins that are encoded by genes on the lac operon. These genes are involved in lactose metabolism.
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1. What type of pedigree is pictured?
a. Autosomal Dominant
b. Autosomal Recessive
c. Sex-linked Dominant
d. Sex-linked Recessive
the autosomal dominant gene, So, the trait must run in the family, and every affected person must have an affected parent; this pattern is frequently referred to as a vertical inheritance pattern.
How do autosomal genes work?A gene's location on an autosome is what is meant by the term "autosomal inheritance" of a gene. Men and women have an equal chance of inheriting the gene, according to this. If a gene is "dominant," it can produce a certain characteristic, including brown eyes rather than just blue eyes, with just one copy of the gene.
Which type of autosomal is most prevalent?The majority of autosomal recessive diseases affecting Caucasians are inherited, with cystic fibrosis being the most prevalent. The illness can manifest clinically in a variety of ways and has an impact on several organ systems.
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Can someone help me
Mountain ranges do not form at these plate boundaries.
a. Divergent
b. Transform
C. Convergent
d. None of the above. Mountain ranges form zt all types of plate boundaries
The correct option is a. Divergent plate boundaries. Mountain ranges do not form at divergent plate boundaries. Instead, these boundaries are characterized by the creation of new oceanic crust through seafloor spreading, which causes the plates to move away from each other. Mountain ranges are formed at convergent plate boundaries, where two plates collide and the heavier plate subducts beneath the lighter plate, leading to volcanic activity and the formation of mountains. Transform plate boundaries are where two plates slide past each other, and they do not typically result in the formation of mountains. However, they can contribute to the formation and movement of existing mountain ranges by causing horizontal displacement along faults.
suppose that the regulators that control cyclin production are no longer produced. hypothesize two possible outcomes.
The regulators that control cyclin production are no longer produced. the two possible outcomes are Uncontrolled Cell Division and Cell Cycle Arrest
If regulators controlling cyclin production are no longer produced, two possible outcomes can be hypothesized:
1. Uncontrolled Cell Division: Cyclins are proteins that regulate the cell cycle by activating cyclin-dependent kinases (CDKs). Without proper regulation, cyclin levels may remain high, leading to continuous activation of CDKs. This could result in uncontrolled cell division, which may eventually lead to the formation of tumors and potentially cancer.
2. Cell Cycle Arrest: On the other hand, if cyclin levels are insufficient due to a lack of regulation, the cell cycle may become arrested at a specific phase. This could result in a decreased rate of cell division or even cell death, as the cell is unable to progress through the necessary stages for division.
In both scenarios, the disruption of cyclin regulation leads to significant consequences for cell growth and division, highlighting the importance of these regulators in maintaining proper cell cycle control.
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Research has identified a species from the west coast of the United States that may have been the ancestor o
28 distinct species on the Hawaiian Islands. What is this species?
A.
The Muir tarweed
B.
Palm trees
C.
The silversword
D. A species ofvine
Research has revealed a species from the American west coast that may have been the progenitor of 28 different species found in the Hawaiian Islands.
What kind of palm tree is the most popular?The most prevalent palm in tropical & subtropical landscapes is A. cunninghamiana, which is also one of the much more popular trees in the group.
How much water do palm palms require?The top 2 inches or more of the soil should only dry out before most palms need to be watered. In order to keep up with the energy they must expend to expand, palms need a substantial amount of water during the scorching summer months when they are doing the most of their growing.
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a genotype resulting from the inheritance of the same alleles from your parents is called___
Answer:
homozygous
Explanation:
Which body system helps with peristalsis as the food travels through the digestive system?
The body system that helps with peristalsis as food travels through the digestive system is the muscular system. Peristalsis is the coordinated contraction and relaxation of smooth muscle layers, which moves food through the digestive tract.
The body system that helps with peristalsis as food travels through the digestive system is the muscular system. The muscular system is responsible for the contractions and relaxation of muscles that move food through the digestive tract. The process of peristalsis is a series of muscular contractions that occur in the digestive tract to move food through the system.
The muscular system is made up of skeletal, smooth, and cardiac muscle tissue. In the digestive system, smooth muscle tissue is responsible for peristalsis.Thus, it is the muscular system that helps with peristalsis as food travels through the digestive system.
The body system that helps with peristalsis as food travels through the digestive system is the muscular system. Peristalsis is the coordinated contraction and relaxation of smooth muscle layers, which moves food through the digestive tract.
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In adult plants, cell division is concentrated in regions called _______
meristem
stoma
wall
Answer: meristem
Explanation:
All of the following represent diagnostic features of chordates except for which one?vertebraeamniotic eggsendothermyadult tunicate
adult tunicate does not represent the features of chordates .
The diagnostic features of chordates include the following:
Notochord: a flexible, rod-like structure that supports the body.
Dorsal nerve cord: a nerve cord that runs along the back and develops into the brain and spinal cord.
Pharyngeal slits: openings in the pharynx that allow water to pass through and filter out food.
Of the options provided, "adult tunicate" is not a diagnostic feature of chordates. Adult tunicates, also known as sea squirts, are actually part of the subphylum Tunicata, which are chordates but lack some of the diagnostic features of the phylum Chordata, such as a notochord and a dorsal nerve cord.
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the population of crayfish on the left represents a population that is q1203 click to view larger image. select one: a. drastically reduced in size by a natural disaster. b. reproductively isolated from all other populations. c. maintaining the same color frequencies over time. d. changing its allele frequencies due to the founder effect.
The given population of crayfish on the left represents a population that is changing its allele frequencies due to the founder effect. The correct option is (d).
What is a founder effect?A founder effect is an occurrence in which a small subset of the population of a species diverges from the population's larger group. The new group may differ in phenotype, genotype, or both from the original population. This phenomenon is known as the founder effect.
It's caused by a chance event that segregates a small number of organisms from a larger population.
According to the question, the population of crayfish on the left is changing its allele frequencies due to the founder effect. Therefore, option (d) is correct.
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flatworms are part of the phylum platyhelminthes, which means flat worm in greek. flatworms have eyespots that help them sense movement around them. what other characteristic do flatworms have?
Flatworms are part of the phylum Platyhelminthes, which means "flatworm" in Greek. Flatworms have eyespots that help them sense movement around them. The other characteristic that flatworms have is that they are bilaterally symmetrical.
This means that they can be divided into two equal halves by a single plane. They have a head and a tail end, and their body is flattened dorsoventrally. Flatworms do not have a coelom, which is a body cavity. This is one of the reasons they are considered a primitive group of animals.
They have a gastrovascular cavity that functions both in digestion and in circulation. Flatworms can be free-living or parasitic. Some parasitic flatworms can cause diseases like schistosomiasis and tapeworm infections.
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the respiratory membrane consists of an endothelial cell of a capillary and the plasma membrane of an alveolar type ______ cell.
The respiratory membrane consists of an endothelial cell of a capillary and the plasma membrane of an alveolar type I cell.
An endothelial cell from a capillary and the plasma membrane from an alveolar type I cell make up the respiratory membrane.
The site of gas exchange between the blood in the pulmonary capillaries and the lungs' air is the respiratory membrane. The thin barrier is made up of the plasma membrane of an alveolar type I cell and the endothelial cell of a capillary, among other layers.
The majority of the alveolar wall is composed of the alveolar type I cell, which is a thin, flat cell. Its plasma membrane joins the capillary's endothelial cell to create a continuous barrier that prevents gases from diffusing into or out of the blood.
Its diffusion barrier is made up of a layer of surfactant, the alveolar type I cell membrane, the type I cell's basement membrane, the capillary endothelium's basement membrane, and the membrane of the endothelial cell. Its thickness is only a few micrometres. This thin barrier enables quick and effective gas exchange between the blood in the capillaries and the lungs' air.
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there is some evidence that pharyngeal slits occur in certain species of echinoderms that appear early in the fossil record. if confirmed, what do these data suggest?
a. Echinoderms are chordates b. Some lineages of echinoderms are more closely related to chordates than others C.Pharyngeal slits should not be used as a tralt in phylogenetics d. Pharyngeal slits were present in the earliest echinoderms and lost later
If confirmed, the data suggest that Pharyngeal slits were present in the earliest echinoderms and lost later that is option D.
Deuterostomes have filter-feeding structures called pharyngeal slits. Pharyngeal slits are repeated openings that appear along the pharynx caudal to the mouth. They may transfer water in the mouth and out the pharyngeal slits while in this posture.
It is suggested that this is how pharyngeal slits originally assisted in filter-feeding, then subsequently, with the inclusion of gills along their walls, aided in breathing of aquatic chordates. These repetitive segments are governed by comparable developmental principles. Some hemichordate species have up to 200 gill slits. At the embryonic stages of tetrapod development, pharyngeal clefts that resemble gill slits are present.
The presence of pharyngeal arches and clefts in the growing human embryo's neck prompted Ernst Haeckel to suggest that "ontogeny recapitulates phylogeny"; while erroneous, this idea includes aspects of reality, as investigated by Stephen Jay Gould in Ontogeny and Phylogeny.
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Regarding the triplet code of DNA, which of the following sentences is true? 1 pike each DNA base codes for three amino acids there are three genes that code for a protein, each amino acid is coded for by three DNA bases each triplet codes for several amino acids
Answer:
The following sentence is true regarding the triplet code of DNA: Each amino acid is coded for by three DNA bases.
Explanation:
The genetic code is a set of rules that specify the correspondence between the three-letter codons in DNA and the twenty standard amino acids used to build proteins. Each codon codes for a single amino acid, except for three "stop" codons that signal the end of the protein sequence. Therefore, a sequence of three DNA bases (a triplet) corresponds to a specific amino acid, and the order of the triplets determines the order of amino acids in the protein sequence.
2. SEP Use Mathematics Using the Math
Toolbox table, complete the equation below
to calculate how much more blood flows per
minute to the skeletal muscles during intense
exercise than during rest.
exercising =
resting = 1,200 cm³/minute
1,200
cm³/minute
4.CC
bla
Answer:
Explanation:
To calculate how much more blood flows per minute to the skeletal muscles during intense exercise than during rest, we need to use the following formula:
exercising - resting = increased blood flow
Substituting the given values, we get:
exercising - resting = increased blood flow
exercising - 1,200 cm³/minute = 4.CC
To solve for exercising, we need to isolate the variable on one side of the equation. Adding 1,200 cm³/minute to both sides, we get:
exercising - 1,200 cm³/minute + 1,200 cm³/minute = 4.CC + 1,200 cm³/minute
exercising = 4.CC + 1,200 cm³/minute
Therefore, the equation to calculate how much more blood flows per minute to the skeletal muscles during intense exercise than during rest is:
exercising = 4.CC + 1,200 cm³/minute
what is a metabolic profile? what determines the metabolic profile of a given bacterial species?
A metabolic profile is the set of chemical reactions and pathways that take place in an organism's cells to sustain life, growth, and reproduction. The genome of a bacterial species is determined by its genetic makeup.
In other words, it is a summary of the metabolic capabilities of an organism. Metabolic profiling involves the identification and quantification of the small molecules involved in cellular metabolism.
The metabolic profile of a given bacterial species is determined by its genetic makeup and the environmental conditions in which it lives. Bacterial metabolism is a complex process that is influenced by a variety of factors, including the availability of nutrients, the presence of other microorganisms, and the physical and chemical properties of the environment.
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collection of codons of mrna, each of which directs the incorporation of a particular amino acid into a protein during protein synthesis called____
The collection of codons of mRNA, each of which directs the incorporation of a particular amino acid into a protein during protein synthesis, is called the genetic code.
The genetic code is essentially a set of rules that specifies how the information encoded in DNA is translated into proteins. The code consists of 64 possible codons, each of which codes for one of the 20 amino acids used to make proteins.
The genetic code is highly conserved, meaning that it is virtually the same in all living organisms, from bacteria to humans. This universality of the genetic code is what allows scientists to transfer genetic material between different species and even kingdoms of life.
The genetic code is read by the ribosome, a complex molecular machine that translates the mRNA sequence into a specific sequence of amino acids that make up the protein. The process of protein synthesis is highly regulated and controlled, and any errors in the genetic code can result in serious consequences, such as genetic disorders or diseases.
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which non-native species reached plague proportions but were finally brought under control in australia after the purposeful introduction of a disease affecting only that species
The non-native species that reached plague proportions but were finally brought under control in Australia after the purposeful introduction of a disease affecting only that species are rabbits.
Non-native species are plant and animal species that do not normally occur in a particular region or country but are introduced through human activities. Non-native species, often known as invasive species, can pose significant problems to ecosystems, native species, and humans.
They might also spread diseases that are harmful to native species and humans, disturb natural habitats, and cause problems in the food chain. They can be introduced to new regions by a variety of methods, including unintentionally or intentionally, by transportation, and by trade.
Here are the measures to control invasive species:
Mechanical control measures: It involves physically removing invasive species from an ecosystem.
Chemical control measures: Chemicals can be used to kill invasive species, and this method has been demonstrated to be very successful in certain circumstances.
Biological control measures: Biological control methods use predators, parasites, and diseases that are native to the invaded ecosystem to manage invasive species.
As a result, in the 20th century, the myxoma virus was purposefully released into the rabbit population, resulting in a significant decline in the rabbit population.
In Australia, rabbits were introduced as game animals in the 19th century. After they established, they grew out of control and caused significant harm to native wildlife and ecosystems.
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a 35-year-old woman has a red, raised rash on the inside of her thighs. gram-stained skin scrapings show large budding cells with pseudohyphae. the infection is caused by group of answer choices staphylococcus aureus. candida albicans. varicella-zoster virus. herpes simplex virus. streptococcus pyogenes.
A 35-year-old woman has a red, raised rash on the inside of her thighs, gram-stained skin scrapings show large budding cells with pseudohyphae. The infection is caused by b. Candida albicans.
Candida albicans are a type of fungus that is commonly found on the skin, mucous membranes, and digestive tract. Candida albicans are a type of yeast that is part of the normal human microbiota, which means they are generally present and benign in the body, even in a healthy immune system. However, Candida albicans can cause infections known as candidiasis when they overgrow or infiltrate the blood or other tissues. Candidiasis, also known as yeast infections, may affect several areas of the body, including the genitals, throat, mouth, and blood.
Candidiasis can manifest as either a local infection or a disseminated or systemic infection, depending on the severity and the patient's immune system's health. The type of candidiasis that affects the skin is known as cutaneous candidiasis, and it can occur in moist, warm areas of the body like the groin and armpits, presenting as a red, raised rash with distinct borders. In contrast, systemic candidiasis is a severe infection that can affect several organs, including the liver, brain, and heart.
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Which of the following is a formal process whereby a certifying agency attests that practitioners have met a standard of
excellence, and the value of such a credential depends on the reputation the agency has in the field?
professional certification
state certification
licensing
accreditation
Professional certification is a formal procedure wherein a certifying body certifies that practitioners have attained a certain level of quality. The worth of such a credential depends on the standing of the agency in the industry.
Professional certificationProfessional certification is the process through which a certifying organization, such as a professional association or an independent certifying body, verifies that a person has the necessary knowledge, abilities, and skills to practice in a certain profession or field.
Professional certification is typically optional and may be granted to people who have satisfied particular educational or training criteria, have proven a certain degree of competence, have passed an exam, or have otherwise complied with the certifying agency's requirements.
Typically, certification is only valid for a set amount of time before it needs to be renewed through continuing education or another method of proving continued proficiency.
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what mechanism causes the cell to stop glowing? choose one: a. reverse transcriptase transcribes sgrna, turning the luciferase gene off. b. the laco operator produces iptg, which then interacts with luciferase, turning the gene off. c. iptg directly interacts with luciferase, turning the gene off and turning dcas9 on. d. when iptg is added, dcas9 interacts with luciferase, turning the gene off.
When IPTG is added, dCas9 interacts with luciferase, turning the gene off. This results the cell to stop glowing. So, option D is correct.
Isopropyl ß-D-1-thiogalactopyranoside (IPTG) is a tool used in molecular biology. It is utilised to promote protein expression in genes where the lac operator is in charge because this substance is a molecular mimic of allolactose, a lactose metabolite that causes transcription of the lac operon.
An example of a CRISPR tool that uses modified CRISPR effectors without endonuclease activity and additional transcriptional activators on dCas9 or the guide RNAs is called dCas9 activation. Similar to CRISPR interference, a complementary guide RNA directs the CRISPR effector to the target.
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In a ______ pair of chromosomes, one member is inherited from the mother, while the other member is inherited from the father.
In a diploid pair of chromosomes, one member is inherited from the mother, while the other member is inherited from the father.
Histone Methyltranferases, Which scientific claim is most consistent with these findings?
Histone methyltransferases are enzymes that regulate gene expression by adding methyl groups to histones, proteins that package and order DNA. The scientific claim that is most consistent with findings on histone methyltransferases is that they play a key role in gene regulation.
Histone Methyltranferases (HMTs) are a family of enzymes that modify histones by adding a methyl group to the amino acid residues in histone tails. This modification changes the chromatin structure and can regulate gene expression. The most consistent scientific claim with these findings is that HMTs play an important role in epigenetic regulation by altering chromatin structure and gene expression through histone methylation.Histone modifications are a part of epigenetic regulation, which refers to changes in gene expression that are not caused by changes in the DNA sequence itself.
Epigenetic changes can be influenced by environmental factors, such as diet or stress, and can be passed down from one generation to the next.HMTs are responsible for the addition of methyl groups to specific amino acid residues in the histone tails, leading to changes in chromatin structure and gene expression. This process is important for normal development and cellular differentiation and can also be disrupted in disease states, such as cancer.Therefore, the scientific claim that HMTs play an important role in epigenetic regulation by altering chromatin structure and gene expression through histone methylation is the most consistent with these findings.
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which of the following is not a zoonosis? puerperal sepsis hantavirus infection anthrax brucellosis tularemia
Among the given alternatives, puerperal sepsis is not a zoonosis. So, the First option is correct.
Puerperal sepsis is not a zoonosis. It is an infection that occurs in women after giving birth, usually as a result of bacteria entering the uterus. The other four diseases listed are zoonoses, meaning they are infectious diseases that can be transmitted from animals to humans.
Hantavirus infection is caused by rodents, such as mice and rats.Anthrax can be contracted by handling infected animals or their products.Brucellosis is typically transmitted through contact with infected animals or their secretions, such as milk.Tularemia, also known as rabbit fever, is a bacterial infection that can be transmitted through contact with infected animals, such as rabbits and rodents.To know more about Puerperal sepsis
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Which statements are TRUE about shield volcanoes? Select all that apply.
eruptions are not generally explosive
have several vents
are formed at divergent boundaries and hot spots
are wide with gentle slopes
The following statements are TRUE about shield volcanoes: Eruptions are not generally explosive. They are formed at divergent boundaries and hot spots. They are wide with gentle slopes.
However, the statement "have several vents" is not always true for shield volcanoes. While some shield volcanoes may have multiple vents, others may only have one central vent. Shield volcanoes are a type of volcano that have a broad, gently sloping shape resembling a shield or a flattened dome. They are formed from low-viscosity basaltic lava flows that spread out and accumulate over time, gradually building up the volcano's shape. Unlike other types of volcanoes, such as stratovolcanoes, shield volcanoes typically have non-explosive eruptions. This is because the magma that feeds shield volcanoes has a low gas content and flows easily, allowing the lava to flow out of the volcano without building up pressure that can cause explosive eruptions.
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