Suggest two reasons why healthy volunteers are used in Phase 1 clinical trials

Answers

Answer 1

Answer:

Healthy volunteers in phase 1 clinical trials are used for the development of safe drugs and other biologics by accepting the possibility of risks from study participation without anticipated health benefits from the investigational products. The incidence of serious adverse events is low.


Related Questions

Match the functions.

1 .
brain
1
Voluntary muscle movements are controlled by the _______.
2 .
blink
The cardiac muscle in the heart is a(n) _______ muscle.
3 .
involuntary
The _______ muscle in the legs is a voluntary muscle.
4 .
smooth
When you move your arm, you using a(n) ________ muscle.
5 .
voluntary
The involuntary muscles in your intestines are ______ muscles.
6 .
striated
When you ______ you can use either involuntary or voluntary muscle movement

Answers

Answer:

1. Voluntary muscle movements are controlled by the Brain.

2. The cardiac muscle in the heart is a(n) involuntary muscle.

3. The striated muscle in the legs is a voluntary muscle.

4. When you move your arm, you using a(n) voluntary muscle.

5. The involuntary muscles in your intestines are smooth muscles.

6. When you blink you can use either involuntary or voluntary muscle movement

Which of the following best describes the relationship between earthquakes and tsunamis?

A
An underwater earthquake can cause a tsunami.

B
Both are the result of big volcanic explosions.

C
Tsunami waves are the main cause of earthquakes.

D
Earthquakes prevent tsunamis from occurring

Answers

Option A. An underwater earthquake can cause a tsunami best describes the relationship between earthquakes and tsunamis.

What is an underwater earthquake or tsunami?

An underwater earthquake or tsunami is a phenomenon in which an earthquake under the aquatic enviroment (i.e. the ocean) may cause the movement of higher waves that are transported to the coastline and thus they may cause neutral disasters, it is for that reason that tsunami is very dangerous and we need to be prepared under this type of situation when alerting the presence of an earthquake in the coastline zones.

Therefore, with this data, we can see that an underwater earthquake or tsunami is a natural phenomenon that may lead to climatic disasters and may be very harmful to human populations located on the coastline of a certain region of the earth, thereby we need to be prepared for these situations.

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For a mutation to have an affect on the species as a whole, it must:
Be neutral and not affect the survival of the individual
Be inheritable and be able to be passed on to offspring
Be able to benefit the individual

Answers

I think it is the second option, that it would be inheritable

In tomatoes, tall vine (T) is dominant to dwarf vine (t), and red fruit (R) is dominant to yellow fruit (r).
A gardener crosses a dihybrid tall tomato plant bearing red fruit with a true-breeding dwarf tomato plant with yellow fruit.

1. Describe the possible phenotypes and genotypes of the plants. Responses should include expected phenotype ratios. Explain your reasoning as needed.
2. If 100 of these tomato plant offspring were planted, how many plants would you predict you would find of each phenotype.


Please help

Answers

Answer:

Possible genotypes: TtRr, Ttrr, ttRr, ttrr

Possible phenotypes: Tall with red fruit, tall with yellow fruit, dwarf with red fruit, darf with yellow fruit

Number of plants with the phenotype:

Tall with red fruit - 25 plants

Tall with yellow fruit - 25 plants

Dwarf with red fruit - 25 plants

Darf with yellow fruit - 25 plants

Explanation:

To find the genotypes create a punnett square like the one in the image

To find the phenotypes examine the genotypes and detemine if they carry a dominant allele for the trait, if they have at least one dominant allele then the dominant trait that will be expressed, if they have two recessive alleles then the recessive trait will be expressed

To find how many plants that will have a phenotype if 100 plants were planted divide the number squares that have a particular phenotype from the punnett squares and divide that number by the number of total squares. Then multiply by 100

4÷16×100 = 25

Environmental science is the study of
a.organismal relationships
b.human impact on the Earth
c.ecosystems
d.all of the above

Answers

Answer:

D.

Explanation:

All of the above since they all belong in environmental science.

Answer:

D it is D!

Explanation:

What base does A always match with in DNA; and what base does B always match with?

Answers

Answer:

well A matches with T, and C matches with G, there is no B

Explanation:

remember this:

-the Apple doesn't fall far from the Tree

-the Car goes into the Garage

Suppose there are two homologous chromosomes. Each chromosome contains a single mutant allele in different parts of the chromosome. How can crossovers be beneficial in this situation

Answers

Answer:

Crossovers can be used in this situation to take the two mutated alleles and combined them which would create a normal allele.

Help plzz^^^

1. predatory advantage

2. camouflage advantage

3. competitive advantage

4. reproductive advantage ​
no links

Answers

I believe it’s answer number 4!

Give me the full meaning of the following questions
1) DNA
2) RNA​

Answers

Answer:

down there.

Explanation:

DNA -> deoxyribonucleic Acid

RNA -> ribonucleic Acid

hence the full meaning of Dna and Rna

Explanation:

Abbreviation of DNA is Deoxyribonucleic acid.

DNA is a group of molecules that is responsible for carrying and transmitting the hereditary materials or the genetic instructions from parents to offsprings.

Abbreviation of RNA is Ribonucleic acid.

RNA helps in the synthesis of proteins in our body.

In hookworm cases where progressive anemia is present, what additional test procedure should be performed to determine infection in stool specimens

Answers

In hookworm cases where progressive anemia is present, the additional test procedure that should be performed to determine infection in stool specimens is the concentration technique.

Hookworms аre nemаtode pаrаsites thаt usuаlly get trаnsmitted through infested soil. They usuаlly аffect the poorest individuаls in tropicаl аnd subtropicаl аreаs. Two species аre mаinly responsible for humаn infections, Аncylostomа duodenаle аnd Necаtor аmericаnus. They cаn cаuse chronic infection of the intestinаl trаct, and suck their host blood, leаding to iron deficiency аnemiа in most cаses. Moreover, pulmonаry mаnifestаtions might occur by the effect of lаrvаl migrаtion.

The stаndаrd method for diаgnosing the presence of hookworm is by identifying hookworm eggs in а stool sаmple using а microscope. Becаuse eggs mаy be difficult to find in light infections, а concentrаtion procedure is recommended.

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If over time, a population has a larger birth rate than death rate, what is happening to the size of that population?

- Staying the same over time
- Decreasing in size
- Decreasing first and then growing
- Growing in size​

Answers

Answer: Growing in size
Explanation: If the birth and death rates are equal, then the population size will not change. However, since the population has a larger birth rate than death rate the population would grow
Answer: growing in size
Explanation: if there is a larger birth rate than death rate that means that there would be more people in the population. That is why the answer is growing in size because the population is expanding and becoming bigger.

What is water used for in space?

Answers

So the astronauts can drink in space

Can you please give me science project ideas that at least 2 weeks, with materials easy to find and that is in the difficulty of 9-10th grade?

Answers

What kind of science project?? Like an experimental one???

Help please and thank you

Answers

Answer:

hey this would be I dont really know I need the points

Use the information in the articles and in the introduction text to explain how gene therapy increase the probability of changing the inheritance of desired traits in people

Answers

According to the information in the articles and in the introduction text,  gene therapy increases the probability of changing the inheritance of desired traits in people by improving the likelihood of a desired trait appearing in the offspring.

What is gene therapy?

Gene therapy is a branch of medicine that focuses on altering a cell's genetic makeup to have a therapeutic impact or to treat a disease by replacing or repairing damaged genetic material.

Gene therapy improves the likelihood of desirable traits and attempts to treat illness or strengthen your body's resistance to illness by replacing a damaged gene or adding a new gene.

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What is the relationship between III-1 to III-2

Answers

Answer:

III 2 IS THE HUSBAND OF III1

What 2 types of point mutations will cause a frameshift mutation?

Answers

Answer:

Insertion and deletion

Explanation:

A frameshift mutation is when the entire reading frame of DNA is shifted, and incorrect.

Frameshift mutations can either be caused by insertion or deletion.

When insertion or deletion occur, a nonsense protein will be made.

So, the correct answer is insertion and deletion.

According to the last resort requirement, weshould try "everything" short of war first.
True False

Answers

The statement that “we should try everything short of war first” according to the last resort requirement is true. This means that before resorting to war, all possible measures should be taken to find a peaceful solution to a problem.

The concept of the last resort requirement is rooted in the idea that war should be avoided at all costs. War is costly in terms of human life, economic resources, and social well-being. Therefore, it should only be used as a last resort when all other options have been exhausted. In other words, war should only be used as a last resort when a situation has become so dire that it is the only remaining option.

It is important to note that the last resort requirement does not mean that war should never be used. It simply means that all other options should be tried first before resorting to war. This can include diplomatic solutions, economic sanctions, and other forms of non-violent intervention. These measures should be used to try and resolve the conflict peacefully before resorting to war.

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Which beaker will have a net movement of water from the cell to the surrounding solution

Answers

Osmosis is the process by which water molecules pass across a cell's partly permeable membrane from a solution with a high concentration of water molecules to one with a lower concentration.

There will be a net transfer of water from the cell to the surrounding solution in a beaker with a hypertonic solution in respect to the cell (also known as osmosis). This is the case because water will flow from a region of lower solute concentration to an area of greater solute concentration in order to balance the solution concentration since osmosis the concentration of solutes in the cell is higher than that in the surrounding solution.

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Which of the following functions is controlled by the cell membrane?
a. excreting waste
b. producing energy
c. replicating DNA
d. assembling proteins

Answers

I think it’s A. Excreting waste

Which of the following must a scientific idea be? Select all that apply. ((NO LINKS))

✰ repeatable
✰ testable
✰ true
✰ modeled
✰ observable

Answers

I think it is repeatable, testable, observable

Compared to the internal salinity of a fish in the ocean, the surrounding seawater would be considered:

Answers

The internal salinity of a fish in the ocean is much lower than that of the surrounding seawater. Generally, the internal salinity of a fish's body is about half to two-thirds of the surrounding seawater.

This is because a fish needs to maintain a balance between the salt and water concentrations inside their body in order to survive. The internal salinity of a fish must remain lower than the surrounding seawater in order for it to remain hydrated. This is done through a process called osmoregulation, whereby a fish is able to take in water while expelling salt.

The salinity of the surrounding seawater is determined by many factors, including the amount of dissolved salts, the temperature, and the amount of rainfall in the area. The salinity of the seawater can also be affected by ocean currents and the proximity to land masses.

Generally, the salinity of the ocean varies depending on the location and is typically between 3.5 and 4.5 parts per thousand. Therefore, when compared to the internal salinity of a fish in the ocean, the surrounding seawater would be considered much higher.

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a cross between ss and Ss will generate _____ % normal hemoglobin, _____% sickle cell trait, and _____% sickle cell anemia.

Answers

A cross between ss and Ss will generate 0 % normal hemoglobin, 50 % sickle cell trait, and 50 % sickle cell anemia.

People with sickle cell trait deliver handiest one replica of the altered hemoglobin gene and seldom have any medical signs and symptoms associated with the sickness. In contrast, humans with sickle cell sickness deliver copies of the altered hemoglobin gene. Hemoglobin S trait, additionally cell  as sickle cell trait, approach that your infant has inherited one gene for the same old hemoglobin (A) from one discern and one gene for hemoglobin S from the alternative discern. motive any fitness problems. Your infant will now no longer want any remedy or remedy for S trait.

A cross between ss and Ss will generate 0 % normal hemoglobin, 50 % sickle cell trait, and 50 % sickle cell anemia.

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Real Question:
Why do our stomachs growl and make noise?
I'll give the brainiest to however really gives a correct or accurate answer.

Answers

Answer:

When you are hungry your brain signals your digestive system to prepare for food. This leads to stomach growling. Your brain does this because it knows that you are hungry, and consequently the brain signals the digestive muscles  to contract. There is also, usually, some gas in the intestines and stomach. The noises come out when the mixture of the gas and fluid, digestive juices, squirt through a opening that separates the stomach and small intestine.

Sometimes the noises happen because of an excessive amount of gas in the small intestine.

What is a bicameral legislature composed of?

Answers

A legislature having two houses is referred to as bicameral. The Lok Sabha & Rajya Sabha are the two houses of the Indian Parliament. There are just a few states in India that also have a bicameral legislature made up of the Vidhan Sabha or Vidhan Parishad, whereas most only have the Vidhan Sabha.

In the United States, bicameral legislatures make up the majority of state and federal legislatures. That is, there are two distinct bodies that make up each legislative.Each party would've been represented inside a balance of power under the bicameral system. In the Senate, where each state would have two senators, representation would be equal, whereas in the House of Representatives, representation would be determined by population.Congress is said to be bicameral if it has both the House of Representatives and the Senate. Due to a compromise the Founding Fathers reached during the Constitutional Convention, we now have two chambers of Congress.

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An organism has the genotype AaBbCc. What is the probability of producing a gamete that only has dominant alleles for these three genes

Answers

A plant having the genotype AABbCC will produce solely ABC and AbC gametes. The 2n formula is used to compute the phenotypes in the cross, whereas the 3n formula is used to calculate the genotypes in the cross.

A cross between the AABBCC and the aabbcc genotypes results in an F1 hybrid with the AaBbCc genotype. An organism produces 2n kinds of gametes,

where n is the number of heterozygous genes present. Because the hybrid AaBbCc is heterozygous for three genes, its total number of potential gametes is 23=8.

The F1 generation plants have the genotype AABbCC. 2n where n= 1 may be used to calculate the number of gametes involved in a specific cross ( n is the number of heterozygotes). As a result, there will be two gametes, ABC and AbC. The phenotype of the F2 generation after selfing these plants will be 3:1, as depicted in the Punnett square.

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Does losing weight help cardiovascular disease?

Answers

Yes, losing weight help with cardiovascular disease.

Even a modest amount of weight loss can have a significant positive effect on cardiovascular health, including enhancement of heart function, reduction in blood pressure, and acceleration of metabolic rate. The Washington University School of Medicine has a research program that is dedicated to understanding the complex relationship between weight and heart health.

The program's work demonstrates that the benefits of weight loss can persist even if some of the weight is regained and that the effort can not only prevent but also reverse significant health problems.

Even after an individual had stopped losing weight and gained a few pounds back, the benefits continued to accrue over the course of many months.

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Beavers build dwellings called lodges. The photo shows one such beaver lodge. Imagine that most of the trees are cut down and removed from the nearby forest. What would be the most likely effect on the beaver population? A. It would increase. B. It would increase and then decrease C. It would stay the same. D. It would decrease.​

Answers

Answer:

D. It would decrease.​

Explanation:

According to this question, beavers (a type of bird) build dwellings on trees called lodges. This means that they find shelter on those trees and will make an habitat of them.

However, if most of the trees are cut down and removed from the nearby forest, there would be almost no tree left for beavers to build their lodges. Hence, causing them to lose their habitat and migrate. This will lead to a DECREASE in population of beavers.

Answer:

D. It would decrease

Explanation:

What if the bunnie i wa breeding had the genotype of WW and WWLL. How many generation would I need to wait to get a hort haired black bunny?

Answers

The generation that must be waited for the offspring of the short-haired black rabbit is the second generation with a probability of 6.25% or 1/16

WW white rabbit genotype, ww black rabbit genotype, LL long hair, ll short hair. If the genotype of a WWll rabbit is crossed with a wwLL then:

Parents: WWll >< wwwLL

Gametes: Wl><wL

Filial: WwLl

100% of their offspring will be white with long hair (WwLl)

If we cross two offspring to create a second generation (both WwLl), we get the following punnett squares:

Parents: WwLl >< WwLl

Gametes:  WL, Wl, wL, w   ><   WL, Wl, wL, wl

Second Filial:

WWLL (white with long hair)

WWL (white with long hair)

WwLL (white with long hair)

Wwll (white with short hair)

WWL (white with long hair)

WWll (white with short hair)

Wwll (white with short hair)

Wwll (white with short hair)

WwLL (white with long hair)

WwLl (white with long hair)

wwLL (black with long hair)

wwLl (black with long hair)

WwLl (white with long hair)

Wwll (white with long hair)

wwlL (black with long hair)

wwll (black with short hair)

The phenotypic ratio of the second generation is 9 (white with long hair) : 3 white with short hair): 3 (black with long hair) : 1 (black with short hair)

The complete questions:

What if the bunnies I was breeding had the genotypes of WWll and wwLL. How many generations would I need to wait to get a short-haired black bunny? Use Punnett Squares to show why.

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During the 1918 influenza pandemic, doctors initially treated infected patients with an antibiotic. Why was this treatment ineffective?

Answers

Answer:

It is because Influenza is a virus.

antibiotics are for bacterial infection.

There is no antiviral drugs till now because virus is non living thing

All we have are vaccines for virus and no medicine

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