The drug development process involves many milestones. To be approved, potential drugs must demonstrate a positive patient outcome with minimization of harm. This is called ________.

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Answer 1

To be approved, potential drugs must demonstrate a positive patient outcome with minimization of harm. This process of examine is simply called Clinical trials.

Recently, significant public investments in health care to find the medical treatments with the highest value have been sparked by the increase in health care expenses in the United States. The American Recovery and Reinvestment Act of 2009 specifically allocated $1.1 billion for "comparative effectiveness" research to assess "...clinical outcomes, effectiveness, and appropriateness of items, services, and procedures that are used to prevent, diagnose, or treat diseases, disorders, and other health conditions." 1 Despite the fact that a variety of study designs can achieve these objectives, randomized controlled trials (RCTs), in particular, continue to serve as the gold standard for comparing disease therapies. Clinical trial execution, however, requires a meticulous strategy based on scientific, statistical, moral, and legal considerations.

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Related Questions

which form of treatment is used to promote the healing process by dilating blood vessels which allows for more circulation to occur in the affected area.

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Vasodilators are medications that cause blood vessels to dilate (dilate). They affect the artery and vein lining muscles, preventing tightening and constriction of the walls. As a result, blood may move through to the valves more easily.

How do vasodilators work?

One condition that these medications serve to treat is excessive blood pressure. Vasodilators are medications that cause blood vessels to dilate (dilate). They affect the artery and vein lining muscles, preventing tightening and constriction of the walls. When the blood passing through the amygdala is warmer than usual, as it is when the system needs to lose heat, the heat-loss center becomes active. This region blocks the production of heat, which expands the skin blood vessels and boosts blood flow, often enough controlling the temperature. When the blood is also still warm, these afferents get to have a signal that stimulates the body's sweat receptors and causes perspiration.

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A nurse is teaching a new guardian how to correctly use a car seat. Which of the following statements by the guardian indicates an understanding of the teaching

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The understanding shown by the new guardian about using a car seat for babies properly is "I should keep my baby in a rear-facing car seat until he is 2 years old."

A baby car seat is a car seat specifically designed for babies or children of a certain age to protect them while in the car. This chair is specifically designed to maintain safety when traveling with children.

Baby car seats are shaped like baskets, usually used for newborns up to a maximum weight of 10 kilograms. The position is facing backward and please pay attention, every baby weighing under 10 kilograms, not even one-year-old must always face the back. Because it is safer for the bones that are not yet strong, especially if the car has to brake suddenly.

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the nurse is teaching the parents how to provide care for their child with sickle cell anemia. which intervention

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....should the nurse prioritize in the teaching plan?

The nurse should prioritize teaching the parents about the signs and symptoms of a sickle cell crisis, and how to administer pain medication, oxygen therapy and hydration as needed.

Sickle cell anemia is an inherited disorder that can cause chronic pain, fatigue, and other complications. The parents should be aware of the signs of a sickle cell crisis, such as severe pain, difficulty breathing, and fever, so that they can take appropriate action to provide relief for the child.

which of the followiing vital signs indicate increased pressure within the skull following head trau,a

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Vital signs indicating increased pressure in the skull after head trauma are headache, double vision, and increased blood pressure.

What is pressure in the skull?

Pressure in the skull is also known as intracranial pressure. This pressure can show the condition of brain tissue, cerebrospinal fluid, and brain blood vessels. Under certain conditions, intracranial pressure can increase and cause certain symptoms that need to be watched out for.

Raised intracranial pressure left untreated can lead to serious, life-threatening conditions. Symptoms include nausea and vomiting, headaches, increased blood pressure, and double vision.

Your question is incomplete. maybe the point of your question is

Which of the following vital signs indicate increased pressure within the skull following head trauma?

Headache, double vision, and increased blood pressure.The body feels feverish and tired

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One of the nurses responsibilities is to educate new parents on the best method to prevent infections in the newborn environment. Which method would the nurse identify as best to control infection

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The method which the nurse would identify as best to control infections is to keep the baby warm and dry as wet diapers can attract bacteria which can cause illness.

The infant is the most susceptible person in the new environment because of lack of enough antibodies and ability to sustain in the new environment and so pre natal care is very important for the child. In this case, the parents must be asked to use antibiotic ointments near the eye of the infant to protect then from ophthalmia neonatorum, infection of umbilical cord etc. The parents must also wash their hands before taking the child as personal hygiene also affects the health of the baby.

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Most denture related infections are caused by ​

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Answer: The answer to this question is chronic candidiasis infection

Explanation: Chronic mucocutaneous candidiasis, a hereditary immunodeficiency disorder, is persistent or recurring infection with Candida (a fungus) due to malfunction of T cells (lymphocytes). Chronic mucocutaneous candidiasis causes frequent or chronic fungal infections of the mouth, scalp, skin, and nails.

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The nurse is using the pediatric Glasgow Coma Scale to assess a child's level of consciousness. What would the nurse assess

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The nurse would assess Grade 5 for verbal response if the child says​ "no" to all questions.

The Glasgow Coma Scale is a clinical scale that is used to accurately assess a person's degree of consciousness following a brain injury. The GCS evaluates a person's ability to execute eye movements, communicate, and move their body. These three behaviours comprise three scale elements: visual, verbal, and motor.

The Glasgow Coma Scale is presented as a cumulative score (ranging from 3 to 15) as well as the results of each test (E for eye, V for Verbal, and M for Motor). The value of each test should be based on the best response that the individual being tested can offer. Some studies have criticised the GCS, citing the scale's low inter-rater reliability and lack of predictive usefulness.

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A nurse is providing teaching to a client who has esophageal cancer and is to undergo radiation therapy. Which of the following statements should nurse identify as an indication that the client understands the teaching?

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The statement that shows that the patient understands the teachings is that they should wash the radiation area with their hands using warm water and mild soap to protect the skin from further irritation. That is option C.

What is radiation therapy?

Radiation therapy is defined as the therapy that applies higher doses of radiation on cancer cells with the purpose of eliminating then from the body cells of an affected individual.

Esophageal cancer is the type of cancer that affects the esophagus which is a long tube that connects the throat to the stomach.

It is the major responsibility to f the nurse to educate the cancer patient about the procedure of the radiation therapy.

The indication that the patient understands the teachings by the nurse is when they reply that they are meant to wash the radiation area with their hands using warm water and mild soap to protect the skin from further irritation.

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Complete question:

A nurse is providing teaching to a client who has esophageal cancer and is to undergo radiation therapy. Which of the following statements should nurse identify as an indication that the client understands the teaching?

Decrease intake of fluid as a way to prevent dehydration.Can maintain close association with partner during therapy.Wash the radiation area with their hands using warm water and mild soap to protect the skin from further irritation.Maintain normal diet during the therapy.

The nurse has provided preoperative instructions to a client scheduled for surgery at an ambulatory care center. Which statement, made by the client, would indicate that further instruction is needed ?
- "The nurse will explain the details of the surgery before I sign a consent."
- "If I do not follow the instructions, my surgery could be cancelled."
- "The physician will update my family after the procedure and provide specific discharge instructions."
- "My medical records will be sent to the ambulatory care center prior to my surgery."

Answers

It is important for the client to have a clear understanding of the surgery and the risks involved before signing a consent form. Therefore, statement "The nurse will explain the details of the surgery before I sign a consent." would indicate that further instruction is needed.

This statement implies that the client may not have been adequately informed about the details of the surgery and may need more information before giving their consent. The other statements made by the client indicate that they understand their responsibilities and the steps that will be taken following their procedure, but statement one implies that they may not have the necessary information to make an informed decision about their surgery.

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A patient suffering from typical leukemic symptoms presents to the emergency room. The physician orders a spinal tap after noticing possible central nervous system involvement. What type of cells are indicated by the red arrows

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The red arrows indicate abnormal leukemic cells. White blood cells are impacted by a particular type of disease called leukaemia.

During a spinal tap, the physician aspirates a sample of the cerebrospinal fluid (CSF) and examines it for the presence of leukemic cells. Leukemic cells have an abnormal appearance and are usually larger than healthy white blood cells. They are easily recognized by their large, round nucleus and lack of a distinct cytoplasm. The red arrows indicate these abnormal leukemic cells.

The presence of these cells in the CSF suggests that the leukemic cells have spread from the blood to the central nervous system and a diagnosis of leukemia is made. Depending on the type of leukemia, the patient may require chemotherapy, radiation, or a bone marrow transplant.

The spinal tap is an important tool in diagnosing and treating leukemia as it can provide a direct sample of the CSF to help determine the extent of the disease.

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What is an appropriate stretching exercise that addresses a low back arch in an athlete who is training in Phase 2: Strength Endurance

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Active kneeling hip flexor stretch is appropriate for addressing a low back arch in an athlete who is training in Phase 2: Strength Endurance.

Hip flexor stretch is the form of exercise that provided various benefits like improved mobility, reduction in pain, improved flexibility and posture. It can be simply called the kneeling exercise where one leg is kneeled down at a time. It can also be done by lying down on the edge of the table.

Strength endurance is the type of muscle strength that requires tension in the muscles for longer durations of time. It is the ability of the body to exert itself but remain active for longer durations of time without suffering any wound or fatigue.

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The nurse is providing teaching about accidental poisoning to the family of a 3-year-old. The nurse understands that a child of

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The nurse understands that a child of this age is at increased risk of accidental ingestion due to a less discriminating sense of taste.

Caustic ingestion happens when a person inadvertently or intentionally consumes a caustic or corrosive material. Depending on the type of the material, the length of exposure, and other conditions, it can cause varied degrees of damage to the oral mucosa, oesophagus, and stomach lining.

Endoscopy of the upper digestive system can identify the degree of the damage, but CT scanning may be more beneficial in determining whether surgery is necessary. During the healing phase, oesophageal strictures may occur, necessitating therapeutic dilatation and the insertion of a stent. Ingestions of acids with pH less than 2 or alkalis with pH greater than 12 can result in the most severe damage.

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The nurse is instructing a client with Parkinson's disease about preventing falls. Which client statement reflects a need for further teaching

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Client statement: "I should try to get up slowly to help prevent falls." This client statement reflects an understanding of the need to move slowly to help prevent falls. No further teaching is required.

What is Client statement?

A client statement is a document that states the position of a client in a business transaction. It is signed by the client and serves as a record of the transaction. The statement outlines the terms and conditions of the agreement, as well as the obligations of both parties. It can be used as evidence in court proceedings, should the need arise. Client statements are often used in the context of contracts, financing arrangements, and other business relationships. They help to ensure that all parties are aware of their rights and obligations, and provide a clear record of the agreement.

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who is a polyvalent nurse​

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Answer:

A specialist is defined as a person who carries out his/her professional duties in the same surgical ward over two years or more; a polyvalent nurse is defined as one who changes their specialty according to the period established by their hospital or according to the needs at any given moment.

Explanation:

Nursing students are studying metabolic disorders of the skeletal system and correctly identify which factor to be the major cause of osteoporosis

Answers

Nursing students are studying metabolic disorders of the skeletal system and aging process is the factor to be the major cause of osteoporosis.

The skeletal system is your body's central frame. It consists of bones and connective towel, including cartilage, tendons, and ligaments. It's also called the musculoskeletal system. The mortal shell is the internal frame of the mortal body.

Osteoporosis causes bones to come weak and brittle — so brittle that a fall or indeed mild stresses similar as bending over or coughing can beget a fracture. Osteoporosis- related fractures most generally do in the hipsterism, wrist or chine. Bone is living towel that's constantly being broken down and replaced.

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Nancy is a staff nurse who works on a rehabilitation unit. Nancy tells you that the assistants are experiencing difficulty with the new lift and wonders what your thoughts are on organizing an in-service training. Nancy is exhibiting which trait of a follower?

Answers

Nancy demonstrates the follower nature of assuming responsibility for identifying a safety concern and concedes authority for the solution to you.

Nursing management includes the effective use of time because management is effective time, the success of clinical manager nurse plans, who have the theory or systematic use of principles and methods related to major institutions and organizations within them, including each unit.

Management skills can be classified into three levels, namely.

Intellectual skills, which include the ability or mastery of theory, and thinking skills.Technical skills include/methods, procedures, or techniques.Interpersonal skills, including leadership skills in interacting with individuals or groups.

The skills that Nancy shows you are interpersonal skills, where she identifies problems but still gives authority to provide solutions to you.

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When inserting a catheter to irrigate a client's colostomy, the nurse meets some resistance. What should the nurse do

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The nurse should stop to prevent the rupturing of a vital internal organ

The nurse is caring for an 8-year-old girl who was in a car accident. Which symptom suggests the child has a cerebral contusion

Answers

Lack of movement in the lower body and a low pulse in the foot

Adderall and Ritalin are legal stimulants with medical uses. Therefore, they can be used:

A.
Without a prescription
B.
Only as prescribed by a medical professional
C.
For off-label (unapproved) purposes
D.
None of the above

Answers

B) Only as prescribed by a medical professional
It would be choice B.) because they’re power substances that are prescribed by professionals so I can confirm the answer above is totally correct

List the various signs and symptoms of decreased cardiac output under the correct category for each.

Answers

The various signs and symptoms of decreased cardiac output include change in the mental status, light-headedness, dizziness, confusion, loss of consciousness, and chest pain, etc.

What factors affects Cardiac output?

Cardiac output is the product of heart rate (HR) and stroke volume (SV) of the heart and it is measured in units of liters per minute. Heart rate is most commonly defined as the number of times the heart beats in one minute. Stroke volume is the volume of blood which is ejected out during ventricular contraction or for each stroke of the heart while beating.

Various signs and symptoms of decreased cardiac output under the correct category include not being able to exercise much, feeling very tired, swelling in the arms and legs, shortness of breath, nausea and vomiting and excessive abdominal pain.

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The nurse is to administer a cyclic feeding through a gastric tube. It is most important for the nurse to

Answers

Answer:

Check the residual volume before the feeding

Explanation:

The nurse will deliver a cyclic feeding through a stomach tube. It also is critical therefore for nurses to lift the bed's head should 45 degrees.

Elevating a head of a bed 30 to 45 degrees helps reduce aspiration into in the lungs. As according to Maslow's hierarchy of needs, this is a priority.

Most patients who are unable to obtain an appropriate oral intake via food or oral nutritional supplements, or who are unable to eat and drink safely, may benefit from nasogastric tube feeding. The purpose of this strategy is to enhance and maintain each patient's dietary intake and nutritional status.

Nasogastric tube (NG tube) is used in individuals with dysphagia who are unable to achieve nutritional demands despite dietary modifications and are at risk of aspiration.

Nasogastric (NG) intubation is a process in which a thin, plastic tube is placed into the nose, down into the stomach, and out. Once an NG tube has been correctly put and secured, healthcare workers such as nurses can directly feed food and medicine to the stomach or take things from it.

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A child with heart failure is on Lanoxin (digoxin). The laboratory value a nurse must closely monitor is which

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A child with heart failure is on Lanoxin (digoxin). The laboratory value a nurse must closely monitor is which serum potassium level

What impacts the heart does Lanoxin have?

It functions by having an impact on specific minerals (sodium and potassium) within cardiac cells. As a result, the heart is put under less stress and is better able to keep up a regular, steady beating.What are the uses of Lanoxin tablets?

Heart failure is treated with lanoxin. Atrial fibrillation, a condition affecting the atria's heart rhythm, is similarly treated with lanoxin (the upper chambers of the heart that allow blood to flow into the heart)

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Collaborating with specialists is an important part of primary care involving patients with neurologic injuries. It isimportant as an APN to know when to refer to a specialist and what the goal of that referral is: furtherinformation, diagnostic testing or treatment recommendations

Answers

It is important as an APN to know when to refer to a specialist when a patient has a neurological injury and the purpose of that referral is for diagnostic testing.

What is a neurological injury?

Neurological injury or nerve injury is a disorder that affects parts of the brain and nervous system. There are various types of neurological disorders, namely :

Multiple Sclerosis is a disease thought to be caused by the environment, genetics, and viruses. This disease is usually characterized by a tingling feeling, numbness, or weakness in several limbs.Alzheimer's is a disorder that often occurs in elderly patients and is usually characterized by memory loss in the brain. Parkinson's attacks nerve cells in the middle of the brain which are useful for regulating the movement system in the body.

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which nursing intervention may be particularly beneficial to an African American patient with insomnia

Answers

Nursing assistance may be especially useful to an African American patient suffering from sleeplessness due to the low cost of test strips & disposable supplies.

Insomnia is a common problem that can make it difficult to get asleep, difficult to remain asleep, or lead you to wake up early and be unable to sleep again. Because everyone's sleep demands varies, there is no defined amount of sleeping hours required to be diagnosed with insomnia. Adults are generally advised to acquire 7 hours of sleep every night.

The majority of instances of insomnia are caused by poor, sadness, anxiety, a lack of exercise, a chronic ailment, or a specific prescription. Symptoms may include trouble falling or staying asleep, as well as a lack of sleep. Insomnia is the most common problem that really can make it difficult to get asleep, difficult to remain asleep, or lead you to wake up early and be unable to sleep again.

Insomnia treatment includes modifying sleep patterns, behavioural therapy, and recognizing and treating underlying problems. Sleeping medications can also be utilized, but the negative effects should be well watched.

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nurse is reading a journal article about the use of real-time ultrasonography, which allows the health care provider to obtain information about the fetus. The nurse would expect the article to describe which type of information

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Nurse is reading a journal article about the use of real-time ultrasonography, and she would expect the article to describe  biophysical profile.

A biophysical profile is a antenatal ultrasound evaluation of fetal well- being involving a scoring system, with the score being nominated Manning's score. It's frequently done when anon-stress test is non reactive, or for other obstetrical suggestions.

A fetus or foetus is the future seed that develops from an beast embryo. After the 9 weeks of fertilization, the fetal period is begun. In mortal antenatal development, fetal development begins from the ninth week after fertilization and continues until birth.

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Cardiocentesis
Prefijo
Sufijo
definicion​

Answers

Answer:

La palabra "cardiocentesis" está formada con raíces griegas y significa "punción que se hace en el corazón para extraer un líquido". Sus componentes léxicos son: kardia (corazón) y kentein (perforar), más el sufijo -sis (acción).

Explanation:

A child has a chronic, nonproductive cough and diffuse wheezing during the expiratory phase of respiration. This suggests:
a.
Asthma.
c.
Bronchiolitis.
b.
Pneumonia.
d.
Foreign body in the trachea.

Answers

A child who has a chronic nonproductive cough and diffuse wheezing during the expiratory phase of breathing. It is possible that the child has A. Asthma

What is wheezing?

Wheezing is a breath sound that sounds like a whistling sound, and is a symptom of a respiratory tract disorder. The most common causes of wheezing are asthma and chronic obstructive pulmonary disease.

Wheezing will generally be heard more clearly when the sufferer exhales, although it can also be heard when inhaling. In some cases, it can be heard when the doctor examines the patient using a stethoscope. Apart from respiratory problems, wheezing can also be caused by allergic reactions or heart disease.

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When assessing distal circulation in a patient's lower extremities, which pulse should you palpate?
- Femoral
- Dorsalis pedis
- Popliteal
- Iliac

Answers

C) Popliteal, Popliteal pulse should indeed be felt when analyzing a patient's adductor muscles for distal circulation.

Distal circulation: What is it?

The term "distal circulation" describes the circulation of blood that takes place in the locations that are farthest remote from the central body. When evaluating distal circulation, there are five basic evaluation that must be produced: capillary refill, color, temperature, impulses, and swelling.

How can my distal circulation be enhanced?

Increase your aerobic exercise. Jogging, for example, is a regular cardiovascular workout that supports and enhances circulation. According to a study, regular cardiovascular exertion is linked to decreased cardiovascular disease and increased cardiac function.

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What should a nurse include in the initial plan of care for a client with the long-standing obsessive-compulsive behavior of handwashing

Answers

The plan that should be included in the plan of care for  a client with the long-standing obsessive-compulsive behavior (OCD) of handwashing is: development of a routine schedule of activities to reduce the need for the ritualistic behavior.

Obsessive compulsive behavior or OCD is the disease where a person suffers from the persistent recurring thoughts or urges to act in a certain way or perform a certain task. It can be explained as the obsessions leading to compulsions.

Ritualistic behavior is the repetitions of any routine or certain behaviors unconsciously. It is one of the most common symptoms of the disease OCD.

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The nurse is inserting a nasogastric tube for a patient with pancreatitis. What intervention can the nurse provide to allow facilitation of the tube insertion

Answers

The nurse is inserting a nasogastric tube for a patient with pancreatitis. The nurse's intervetion is that as the tube is being put in, let the patient drink some water.

A plastic tube is inserted through the nose, down the oesophagus, and into the stomach during a procedure known as nasogastric tubation. A comparable procedure involves inserting a plastic tube into the mouth during orogastric intubation. The NG tube was created by Abraham Louis Levin.

The nose, throat, and stomach are all entered by a small, soft tube known as a nasogastric (NG) tube. The formula is typically given to children who are unable to eat by mouth. Children occasionally receive medicine through a tube.

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