What are the most common mutations in SCID?

Answers

Answer 1

A mutation in the interleukin 2 receptor gamma (IL2RG) gene, which makes the common gamma chain subunit, a part of multiple IL receptors, causes X-linked SCID. JAK3 is a crucial signaling molecule that is activated by IL2RG. SCID can also be brought on by a JAK3 chromosome 19 mutation.

Due to mutations in the gene encoding the common chain for several cytokine receptors, X-linked SCID is the most prevalent kind. Adenosine deaminase deficiency (ADA def.) and IL-7R-chain deficiency are the second and third most frequent causes, respectively.

The term "combined immunodeficiency" refers to a genetic abnormality that affects T cells as well as at least one other kind of immune cell in SCID patients. According to which immune cells—T, B, and/or NK cells—are damaged, different types of SCID are categorized.

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Related Questions

Find the equivalent resistance of this
circuit.
Ri
R2
1002 2202
R3
w
320 12

Answers

Answer:

Re=160ohm

Explanation:

Step#1

Rt=R1+R2 ( because both are in series)

Rt=(100+220 ) ohm

Rt=320 ohm

Step#2

Rt and R3 are parallel so,

Re= (Rt× R3) ÷ (Rt+R3)

Re= (320×320)÷( 320+320)

Re = 102,400÷ 640

Re=160ohm

How does using myNav Accenture to help its client become more sustainable?

Answers

Accenture can assist its clients in being more sustainable thanks to the myNav. By making it easier to create cloud solutions that lower carbon emissions by rearranging manufacturing facilities such that carbon emissions can be calculated with ease.

by establishing new corporate efforts to lower transportation expenses and by establishing new rules for the disposal of out-of-date technology.

​reduces the expense of transportation

creates a design that is appropriate and aids the customer in becoming more sustainable.

establishes sustainable guidelines for disposing of outdated technology.

myNav Green Cloud Advisor assists businesses in developing cloud solutions that cut carbon emissions and create a platform for ethical innovation. Green Cloud Advisor starts by establishing a baseline for the energy usage, compute needs, and sustainability objectives of current data centers.

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Seismic waves carry energy from earthquakes through the earth's crust. Seismic waves are...

- transverse waves only

- longitudinal waves only

- neither transverse nor longitudinal waves

- both transverse and longitudinal waves

Answers

Answer:

- longitudinal waves only

Explanation:

The P seismic waves travel as elastic motions at the highest speeds. They are longitudinal waves that can be transmitted by both solid and liquid materials in the Earth's interior.

A paper airplane is thrown with an initial velocity of 2.4 m/s and an angle of 60°. Find the voy

Answers

Initial velocity of 2.4 m/s and an angle of 60°.

The x component is 2.4 m/s cos(60°) = 2.4 m/s (0.5) = 1.2 m/s

The y component is 2.4 m/s sin(60°) = 2.4 m/s (0.866) = 2.08 m/s

What is Initial velocity?

Initial velocity is the speed an object has when it starts moving in a certain direction. It is the speed that an object has before any external forces act upon it. Initial velocity is a vector quantity, meaning it has both a magnitude, or size, and a direction. Initial velocity is usually measured in meters per second (m/s). It is important to note that the initial velocity of an object can be different depending on the reference frame from which it is measured.

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The complete question is-

A paper airplane is thrown with an initial vclocity of 2,4 m and angle of 60" Find the Voz: 012m/s 0.62 mn/& 0 1.70 m/8 208 m/$

Which of the following reactions will delay the decay of a fruit?

Answers

Answer:

placing it in the refrigerator

a 0.30g fly moving at 1.5ms-1 is trappedby a spiders web the fly comes to rest in a time of 0.40s calculate the magnitude of the change in momentum if the fly and the average firce exerted by the web on the fly​

Answers

Answer:

Magnitude of the change in momentum = 0.45kgms-1

Force exerted = 1.13N

Explanation:

The magnitude of the change in momentum of the fly can be calculated using the equation Δp = mv, where m is the mass of the fly and v is the velocity of the fly. In this case, the fly has a mass of 0.30g and an initial velocity of 1.5ms-1. Therefore, the change in momentum of the fly is

Δp = (0.30g) x (1.5ms-1) = 0.45kgms-1.

The average force exerted by the web on the fly can be calculated using the equation F = Δp/Δt, where F is the average force, Δp is the change in momentum of the fly, and Δt is the time taken for the fly to come to rest. In this case, the change in momentum of the fly is 0.45kgms-1 and the time taken for the fly to come to rest is 0.40s. Therefore, the average force exerted by the web on the fly is

F = (0.45kgms-1)/(0.40s) = 1.13N.

Why is countercurrent flow better for dialysis?

Answers

The countercurrent flow is better for dialysis because-

The dialysate flows in the opposite direction from the blood. More urea and creatinine are removed from the blood as a result of the dialysate and blood flowing counter-currently, which optimizes the concentration gradient of solutes between the two fluids.

All throughout the dialyzer's length, countercurrent flow optimizes the concentration gradient between blood and dialysate Small solute clearance falls by 10% when blood flow and dialysate flow are cocurrent (moving in the same direction). Because they produce a more consistent temperature difference between the fluids along the whole length of the fluid channel, counter flow heat exchangers naturally outperform parallel flow heat exchangers in terms of efficiency.As an illustration, a faster blood flow rate boosts clearance by increasing the volume of blood evacuated each minute7. Additionally, a quicker dialysate flow rate results in more solutes being removed from the dialysate fluid, increasing the concentration gradient and the clearance rate8–10.

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Two waves meet while traveling through the same medium. The crests of wave one meet up with the crests of wave two. If wave one has an amplitude of 4 and wave two has an amplitude of 3, what is the amplitude of the wave resulting from the interference

Answers

If wave one has an amplitude of 4 and wave two has an amplitude of 3, what is the amplitude of the wave resulting from the interference

Equation Used

The resulting intensity is calculated as follows: I = (sqrt(I1)-sqrt(I2))2

3 variables and 1 function are used in this formula.

Used Functions

Square root function and sqrt (Number)

used variables

The effect of two intensities coming together is called the "resulting intensity" (measured in candela).

The energy that the first wave transfers over a surface of a given area in a unit of time is measured as intensity 1 (measured in candela), which is equal to the energy density times the wave speed.

The energy that the second wave transfers over a surface of a certain area in a unit of time is measured as intensity 2 (measured in candela), which is equal to the energy density times the wave speed.

No conversion is necessary for intensity 1: 4 candela to 4 candela.

Intensity 2: No Conversion Needed 3 Candela to 3 Candela

Replacement of Input Values in a Formula

I is equal to (sqrt(I1)-sqrt(I2))2 --> (sqrt(4)-sqrt(3)).

2 Assessing...…

I = 0.0717967697244909

Candela: 0.0717967697244909 No Conversion Is Necessary

RESULT 0.0717967697244909 A candela Outcome Intensity (Calculation completed in 00.016 seconds)

What is Wave Interference?

When two waves that are moving in opposite directions arrive at the same location simultaneously, interference results. The two waves will combine into a temporary, larger wave with an amplitude equal to the sum of their individual amplitudes if their crests and troughs completely line up. Constructive interference is what this is. On the other hand, if the crests of two waves coincide, they either combine to form a smaller wave or completely cancel each other out. We refer to this as destructive interference.

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A 2.6-mm-diameter sphere is charged to -4.4 nC. An electron fired directly at the sphere from far away comes to within 0.32 mm of the surface of the target before being reflected.
a. What was the electron's initial speed?
b. At what distance from the surface of the sphere is the electron's speed half of its initial value?
c. What is the acceleration of the electron at its turning point?

Answers

The correct answer to the given question is -6.944 * 10^-28 Joules

a. To find the electron's initial speed, we can use the conservation of energy. The initial kinetic energy of the electron must equal the final potential energy of the electron at its closest approach to the sphere.

Ki = 1/2 * me * v^2

v = sqrt(2Ki/me)

Ki = qe * V = (1.6 x 10^-19 C) * (-4.4 x 10^-9 C) = -6.944 x 10^-28 J

b. At the point where the speed of the electron is half of its initial value, the kinetic energy of the electron is half of its initial value. Therefore,

Ki/2 = 1/2 * me * (v/2)^2

we can solve for the distance from the surface of the sphere using the same equation as in part a, and substituting Ki/2 and v/2 for Ki and v respectively

c. The acceleration of the electron at its turning point can be found using the equation for centripetal acceleration:

a = v^2/r

where a is the acceleration, v is the speed of the electron, and r is the distance of the electron from the center of the sphere at its closest approach. We can use the value of v from part a and the distance from part b to find the acceleration.

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Part E
How much potential energy does the roller coaster have at the top
of the second hill2 Use your answers from parts C and D to
determine the answer.

Answers

Answer:  

416,500 J – 67,200 J = 349,300 J

The potential energy at the top of the second hill is 349,300 joules.

Answer:

The potential energy at the top of the second hill is the potential energy at the top of the first hill minus the potential energy lost from friction:

416,500 J – 67,200 J = 349,300 J

The potential energy at the top of the second hill is 349,300 joules.

Explanation:

This answer came straight from the website of Edmentum.

the goal of condensed matter physics is to explain all the properties of matter by its electronic configuration

Answers

The study of the macroscopic characteristics of materials is known as condensed matter physics.

It attempts to predict the collective behaviours of extremely large quantities of electrons, atoms, or molecules using the well-established rules of microscopic physics.

More unusual condensed phases include the Bose-Einstein condensate found in ultracold atomic systems, the ferromagnetic and antiferromagnetic phases of spins on crystal lattices of atoms, and the superconducting phase displayed by some materials at low temperatures. Condensed matter physicists use experiments to measure different material properties and mathematical models developed by using the physical laws of quantum mechanics, electromagnetism, statistical mechanics, and other theories to understand how these phases behave.

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A classroom has a volume of

165 m^3. How many moles of gas

are in the room if the temperature

is 20. 0°C and the pressure is

1. 00 atm?

(Make sure to put P, V, and I

in the right units. )

(Unit = mol)

Answers

The number of moles in the room which has a volume of 165 m³ is 0.0686 moles

The volume of the classroom = 165 m³

The temperature of the room = 20°C

                                                 =  293 K

The pressure = 1 atm

The number of moles in the room can be found using the formula,

              PV = nRT

where P is the pressure

          V is the volume

          n is the number of moles

          R is the gas constant

          T is the temperature

Let us rearrange the above equation, we get

         n = PV/RT

Let us substitute the known values in the above equation, we get

        n = 1 x 165 / 8.21 x 293

           = 165 / 2405.53

           = 0.0686 moles

Therefore, the number of moles in the room is 0.0686 moles

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a book with a mass of 0.25 kg is lifted 2 m onto a bookshelf. how much gravitational potential energy does it gain? ( g = 10 N/kg)​

Answers

Gravitational Potential Energy = mass x gravity x height

(Gpe=mgh)

0.25 x 10 x 2 = 5J

hello please help i’ll give brainliest

Answers

Answer:

B

Explanation:

They move at a rate of one to two inches (three to five centimeters) per year.

Deviance has an effect on social power. How is this BEST demonstrated?


A. Powerful people in society keep their power by defining the laws of deviant behavior.


B. People with little power perform more questionable acts with fewer consequences than the more powerful people.


C. All groups that follow cultural norms tend to have a large amount of social power in society.


D. Someone who doesn't follow norms in a society always gains power because other people will rebel with them.

Answers

Deviance has an effect on social power. Then, Powerful people in society keep their power by defining the laws of deviant .

Forms of Deviant Behavior Deviant Behavior Based on Nature

Based on the nature is divided into two kinds, namely negative behavior and positive behavior.

a. Positive deviant behavior

Positive behavior is deviant behavior that gives or has a positive impact on social life, because it has innovative elements and ideas that emerge are also creative, so as to enrich people's insights.

Positive behavior is also directed primarily at the values to be achieved together as well as social interests and is often considered as something ideal in society. Positive behavior will usually be accepted by society, because it is a form of development and adjustment to the times.

b. Negative deviant behavior

Negative behavior is the opposite of positive behavior.

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Answer:

a

Explanation:

the air leaves the balloon in one direction; the car moves in the opposite direction. This balloon car illustrates for action, there is an equal and opposite reaction or?

Answers

Answer:

Newtons 3rd law

Explanation:

If you need to stop quickly and your vehicle is not equipped with an Anti-Lock Braking System (ABS), you should:

Answers

It is important to note that vehicles without ABS may take longer to stop and have a greater risk of skidding or losing control, so it's important to be aware of the stopping distance and to drive with caution.

What is ABS?

Anti-Lock Braking System (ABS) is an advanced safety feature that is commonly found in modern vehicles. It is designed to prevent the wheels of a vehicle from locking up during braking, which can cause the vehicle to skid and lose control.

If you need to stop quickly and your vehicle is not equipped with an Anti-Lock Braking System (ABS), you should:

Press the brake pedal firmly and steady, do not pump the brakes.

Steer the vehicle in the direction you want to go.

Avoid locking up the wheels by applying the brake pressure smoothly and progressively.

If the wheels lock, release the brake pedal slightly to regain traction and then reapply the brake pressure.

Keep a safe distance from the vehicle in front of you to give yourself more time to react and stop.

Hence, by following the above mentioned steps you can quickly stop a car not equipped with ABS.

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9. Does the amount of work on the household object change if you lift the object faster? Why or why not? because​

Answers

Answer:

nvwngviuvnbowibnoijbdofij

Explanation:

A crane does 900 Joules of work in 40 seconds. What amount of power did it have?

Answers

power = workdone/timetaken

=900/40

=22.5W

Answer:

900/40

22.5W

Explanation:

power =

Work done / time taken =

=900/40

=22.5W

Does rain occur most often in warm air masses, cold air masses or at warm fronts where two meet and interact?

Answers

Answer:

at warm fronts where two meet and interact

Explanation:

Warm fronts often bring stormy weather as the warm air mass at the surface rises above the cool air mass, making clouds and storms

ps. I'm not very sure if it's correct

For which of the regions shown in the figure is the observed effect the strongest? O Region B O Region C
O The observed effect is the same for all three regions O Region A

Answers

D) Region A. The observed effect is strongest in Region A, as this region contains the most extreme temperatures and the most extreme change in temperature over time.

What is temperatures ?

Temperatures refer to the degree of hot or cold that something is. It is typically measured in either Celsius or Fahrenheit, with Celsius being the most common metric used.

Temperatures can range from extreme cold to extreme heat, with average temperatures ranging from -40 to 40 degrees Celsius. Temperatures can be affected by a number of factors, including altitude, latitude, and proximity to the ocean. Different climates can experience vastly different temperatures, making it important to know the temperature of a particular area before traveling.

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Uma wants to recreate the discovery of superconductivity. Which describes the materials needed?

A) a tool to increase temperatures, copper, resistance, a tool to measure electric current
B) a tool to drop temperatures, mercury, an electric current, and a tool to measure resistance
C) a tool to drop temperatures, mercury, resistance, a tool to measure electric current
D) a tool to increase temperatures, copper, an electric current, and a tool to measure resistance

Answers

Answer:

B)a tool to drop temperatures, mercury, an electric current, and a tool to measure resistance

B a tool to drop temp

What is the process called when the ice reaches the coast breaks off to form icebergs that are then carried out to sea?

Answers

The process of breaking of ice from the edge of the glaciers and then carried out to sea is known as calving.

Calving of glaciers is usually accompanied by a loud cracking sound or booming sound.

A huge glacier or polar ice that has broken off and floated into the sea is what creates an iceberg. The iceberg is composed of fresh water, just like the glaciers or ice in the North Pole. Since freshwater is less thick than salty seawater, icebergs float in the water.

When a rift develops in a glacier's margin as a result of ice melting, wind or water erosion, or other factors that make the glacier unstable, the calving process begins. A block eventually separates from the land, forming an iceberg that crashes into the water.

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name an instrument that is used to produce high pitched notes

Answers

Answer:

The smaller instruments, the violin and viola, make higher-pitched sounds, while the larger cello and double bass produce low rich sounds

[tex]hey \: i \: am \: new \: here \: nice \: to \: meet \: you[/tex]

Answer:

base ,violin,cello are some

A girl on a skateboard (total mass of 40 kg) is moving at a speed of 10 m/s at the bottom of a long ramp. The ramp is inclined at with respect to the horizontal. If she travels 14.2 m upward along the ramp before stopping, what is the net frictional force on her

Answers

Long ramp would be the net static friction acting on her if the ramp has a total weight of 40 kg is  F = 6.77 N.

What is the force's overall net force?

The effects (the sum) of any and all pulling and pushing forces that are actually acting on an object is known as the net force. An item will speed up in the net force if the pushing and pulling forces acting on it are not equal (a net force acts).

Calculation -:

E(f) - E(i) = -F(k)d

E(f) = mgy(f) = 1/2×mv²(f)

E(i) = mgy(i) + 1/2×mv²(i)

F(k) = [E(f)- E(i)]/-d

= {mgy(s) + 1/2mv²(f) - (mgy(i) + 1/2mv²(i))}/-d

F(k) = {(40)(9.8)(14.2)(sin[tex]20^{o}[/tex]) +0-(0+1/2(40)([tex]10^{2}[/tex])}/-14.2

F(k) = 6.77 N

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Describe a method that can be used to open a tight lid of bottle without damaging it

Answers

Answer:

But the safest way to loosen a tight cap may be to run hot water on it so that it expands slightly.

Explanation:

7.) A 72 kg skier is beginning to ski down a slope starting 90 meters high. There is an issue, the skier did
not see a curb in the slope and did not realize they were going to hit a wall at the bottom of the slope. It
was observed by a nearby instrument that when the skier collided with the wall of snow there was 64 J
of sound energy given off. The rest of the kinetic energy was converted to heat energy, what was the
amount of kinetic energy converting to heat from the collision?

Answers

The total energy of the skier at the beginning of the slope is 63360 J.

What is total energy?

Total energy is the sum of all the energies of a system, including thermal, mechanical, electrical, and chemical. It is the measure of the capacity of a system to do work. It can be expressed as the product of the mass of the system and its velocity squared.

The kinetic energy of the skier at the beginning of the slope is given by the equation KE = .5mv^2, where m is the mass of the skier (in kilograms) and v is the velocity of the skier (in meters per second).

The kinetic energy at the beginning of the slope is (0.5)(72kg)(0m/s)^2 = 0 J. Since the skier was 90 meters high, we can assume a gravitational potential energy of (90m)(9.8m/s^2)(72kg) = 63360 J.

Therefore, the total energy of the skier at the beginning of the slope is 63360 J.

At the end of the slope, the skier converts the energy into sound and heat energy. The sound energy of 64 J is given. Therefore, the heat energy must be 63360 - 64 = 63296 J. This is the amount of energy converted to heat energy from the collision.

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A ball is thrown upward from the ground with an initial velocity of 2.13 m s-1. How long does the ball take (in millisecond, ms) to reach the maximum height

Answers

The time it takes for the ball to reach its maximum height is 745 milliseconds.

What is time?

Time is defined as a scalar quantity that describes the progression of events in the universe. It is often considered to be the fourth dimension of spacetime, along with the three dimensions of space. Time is closely related to the concepts of causality, or the relationship between cause and effect, and is considered to be a fundamental aspect of the physical universe.

To find the time it takes for the ball to reach its maximum height, we need to use the equation:

1/2 * a * t^2 + v * t + d = 0

where a is the acceleration due to gravity (-9.8 m/s^2), t is the time, v is the initial velocity (2.13 m/s), and d is the initial displacement (0 m, since the ball is thrown upward from the ground).

We know that the ball is thrown upward and reaches its maximum height, so it is subject to a constant acceleration due to gravity in the downward direction. Therefore, the acceleration is -9.8 m/s^2.

The time to reach the maximum height can be found by solving the above equation for t.

t = sqrt(-2*d/(a+v))

t = sqrt(-2*0/(-9.8+2.13))

t = sqrt(2*2.13/(9.8-2.13))

t = sqrt(4.26/7.67)

t = sqrt(0.555)

t = 0.745s

To get the time in milliseconds:

t = 0.745s * 1000ms/s = 745 ms

Therefore, the time it takes for the ball to reach its maximum height is 745 milliseconds.

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. Two spherical objects have masses of 8,000 kg and 5.0 kg. Their centers are separated by a distance
of 1.5 m. Find the gravitational attraction between them.

Answers

Two spherical objects have masses of 8000 KG and 1500 KG their centers are separated by a distance of 1.5 M, the gravitational attraction between them is 3.56 × 10⁻⁴N.

How does gravitational force work?

The gravitational force, also known as gravity, pulls objects with mass in the same direction. We frequently think about the Earth's gravitational pull. This force is firmly holding your body in place. But every mass-bearing object attracts other mass-bearing objects toward it through gravity.

Using the formula of gravitational attraction

F = G× M₁M₂/d²

where G = 6.67 × 10⁻¹¹ Nm²Kg⁻²

M₁ = 8000Kg

M₂ = 1500 Kg

F =  6.67 × 10⁻¹¹ × 8000 × 1500 / (1.5)²

F = 3.56 × 10⁻⁴ N

The gravitational force of attraction between them is 3.56 × 10⁻⁴ N.

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[tex] \huge\mathcal\colorbox{red}{\color{pink}{クエスト}}[/tex]
Explain,'The Theory of Relativity' briefly.​

Answers

Answer:

The theory of Relativity state that :Special relativity applies to all physical phenomena in the absence of gravity and General relativity explains the law of gravitation and its relation to other forces of nature.

Question ↷Explain,'The Theory of Relativity' briefly.Answer ↷Composed of two non correlative theories both given by ,'Einstein' , namely ,"Special relativity" & "General relativity".Special Relativity states that physics laws works the exact same for each and every inertial objects and also that light's speed in vaccum isn't dependent on the motion of it's respective observer.General Relativity states that Gravity dilates the time and It affects the spacetime by bends , stretches and compression .Time slips more leisurely where the gravity is strong and vice versa.

[ You're welcome,my past self!]

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Identify the 13 c nmr chemical shift for each carbon atom in a molecule of 1-penten-3-one LAB: User-Defined Functions: Step counter A pedometer treats walking 2,000 steps as walking 1 mile. Define a function named Steps To Miles that takes an integer as a parameter, representing the number of steps, and returns a float that represents the number of miles walked. Then, write a main program that reads the number of steps as an input, calls function Steps ToMiles with the input as an argument, and outputs the miles walked, Output the result with four digits after the decimal point, which can be achieved as follows: Put result to output with 4 decimal places If the input of the program is: 5345 the function returns and the output of the program is: 2.6725 Your program should define and call a function: Function Steps ToMiles(integer userSteps) returns float numMiles 361108 2293206.qx3zay LAB ACTIVITY 5.9.1: LAB: User-Defined Functions: Step counter 0/10 1 Variables Not shown when editing Input Output Code Flowchart ENTER EXECUTION STEP RUN Execution speed Medium Submit for grading Signature of your work What is this? What does the second law of thermodynamics tell us about? Expresar una idea contrapuesta o contraria (aunque) is this para What is the main message of Churchill's finest hour speech? PLEASE HELP ME TYSM IF YOU DO!!! Help^^^^^^^^^^^^^^^^ Easy question will give brainliest and 15 ptsLucy graphed a system of linear equations.What is the solution to the system of equations?A. (-4, 2)B. (-1, 3)C. (0,2)D. (2,4) Why did labor strikes become a regular occurrence during the Gilded Age? Your pet turtle and your pet bird look and act differently. What has DNA evidence revealed about the relatedness of reptiles and birds a copy machine can make 500 copies every 4 minutes. how many minutes per copy? Find the reference angle for a rotation of 347. Hey could anyone solve these, you dont have to include math! Just the answers! The question is in the picture I would appreciate if you could explain how to get the answer thank you. why do you think these counties were allowed the greatest number of immigrants What is the acceleration when t 0? The function f open argument x close argument varies inversely with x and f open argument x close argument equals 0.5 when x Jamie wants to focus on selling her overstocked blue saucepans. She sets up keywords using a broad-match modifier. What are two ways the broad-match modifier makes Jamie's work easier? (Choose two.) What is this expression in simplified form?(22) (52)O A. 1011O B.1211O c.20v/11OD. 24/11 Which lines from "After Apple Picking" best support a theme related to the result of doing too much? A. "One can see what will troubleThis sleep of mine, whatever sleep it is." B. "Of apple-picking: I am overtiredOf the great harvest I myself desired." C. "But I was wellUpon my way to sleep before it fell," D. "The scent of apples: I am drowsing off.I cannot rub the strangeness from my sight"